Mattress Thickness and Its Impact on Sleep Quality Mattress thickness is an important consideration when selecting the perfect mattress for your sleep needs. The thickness affects the level of comfort a mattress can provide and can influence the overall experience. Thicker Mattresses for Enhanced Comfort Thicker mattresses, usually ranging from 12 to 16 inches, tend to provide greater comfort, especially when combined with high-density foam layers or inner coil systems. Thicker mattresses can also offer extra cushioning, making them ideal for people with back pain.